Poster Presentation

Poster Title : The Effects of Neoadjuvant and Adjuvant Chemotherapy in Locally Advanced Muscle-Invasive Bladder Cancer: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Author : Grace Filbertine, Sasivimol Rattanasiri and Ammarin Thakkinstian

Abstract : Objective: A systematic and meta-analysis from individual patient time-to-event data were performed in order to assess the effect of neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC) in the treatments of patients with locally advanced muscle-invasive bladder cancer (MIBC). Methods: Randomized controlled trials (RCTs) comparing the effect any pair of treatments (i.e., NAC, AC, and local treatment) on locally advanced MIBC cancer were identified from MEDLINE, SCOPUS, and WHO-ICTRP databases. Overall survival (OS) probabilities and times were extracted from Kaplan-Meier (KM) curves using Digitizer program and converted to individual patient time-to-event data. A one-stage mixed effect survival model was applied to estimate the median OS and hazard ratio (HR). Results: A total of 9 RCTs (1,415 patients) were selected. The median OS of NAC and AC were longer than local treatment (52.9 vs 43.0 months) and (61.9 vs 54.3 months) with HR (95% CI) of 0.83 (0.71, 0.97) and 0.89 (0.64, 1.23), respectively. Conclusion: NAC and AC could be beneficial in patients with locally advanced MIBC.

Poster Title :Strengthening Local Government Policies on Malaria Health Services
Author : Farindira Vesti Rahmasari, Arief Kurniawan Nur Prasetyo, Winny Setyonugroho, Agustiyara, Fadlin Humaira

Abstract : Introduction Malaria health services are an important aspect that requires more attention from the government. This study analysed the role of local governments in implementing health services and the relationship between local government programs and malaria cases. In 2019-2020 malaria cases have decreased significantly, with a previous history of having fluctuating cases. This is a major concern, because Purworejo Regency is in the stage of being eliminated. Methodology This study used quantitative correlational method. Questionnaire was used to collect the data which came from four sub-districts in Purworejo. Results and Discussion Government programs have a correlation with local health services, as proven by 0.835. The better the government program, the better local health services. Government programs also have a correlation with malaria cases (0.713). Conclusion Purworejo Regency is proven capable in implementing the national malaria health program synergy with regional health programs to reduce the number of malaria cases.

Poster Title : Antioksidant and Cytotoxic Activity of Ethanol Fraction of Roselle Calyx (Hibiscus sabdariffa L.) Against WiDr Colon Cancer Cells Line by In Vitro and in Silico Assay
Author : Rifki Febriansah, B.Innya Untari Afriana, Nabila Kaulika1, Muhammad Taher Bakhtiar

Abstract : The incidence of colon cancer in Indonesia is relatively high. Colon cancer treatment has many side effects. Therefore, it is needed to develop colon cancer drugs from natural ingredients such as roselle calyx (Hibiscus sabdariffa L.) as chemopreventive to increase efficacy and reduce the side effects. This study aims to identify the potential of ethanol fraction of roselle calyx (FEBR) that contains flavonoid cyanidin-3-sambubioside as antioxidant, cytotoxic, and ability to inhibit the growth of cancer cells. The methods used were in vitro and in silico. Roselle calyx was macerated and fractionated by Thin Layer Chromatography (TLC) which was used to identify flavonoid in FEBR qualitatively. Antioxidant test of FEBR was measured by DPPH. Cytotoxicity test in WiDr cell line to find out cell viability was conducted by using MTT Assay method. The cell cycle of each cell was analyzed to find out the cell cycle phase by using flowcytometry method. Molecular docking of FEBR with an active compound of cyanidin 3-sambubioside in IKK and VEGF was analyzed by using Autodock Vina method. The TLC result for flavonoid in FEBR showed dark violet and violet spot in UV 366. Antioxidant and cytotoxic tests of FEBR had weak ability with IC50 428 µg/ml and 3127 µg/ml, respectively. Cell cycle inhibition on each cell occurred in the M1 phase. The result of molecular docking showed inhibitory activity of FEBR in IKK and VEGF with affinity energy of -9.6 kcal/mol and -6.7 kcal/mol.

Poster Title : An Analysis of Coronavirus Disease Mitigation through New Media by the Provincial Government of Special Region of Yogyakarta
Author : Ajeng Putri Andani, Roiyan Nangim, Bayu Mogana Putra, Sumekar Tanjung

Abstract : The Special Region of Yogyakarta (DIY) has been announced as one of the regions in Indonesia with the best handling of Covid-19. One of the COVID-19 mitigation actions taken by the government of DIY, particularly in the information sector. This study aimed to determine the communication strategy implemented by the government of DIY in handling the covid-19 pandemic through Instagram account @humasjogja and website Instagram account is used as the media to deliver key information of the Covid-19 cases in DIY and technical guidance on covid-19 that must be followed by society. Meanwhile, the website is used to disclose information, detailed information related to the confirmed cases in DIY, to information related to what the Government has done. Therefore, the use of new media as a mitigation of covid-19 information is appropriate and will even be better if supported by public awareness to combat the Covid-19 pandemic in DIY.

Poster Title :Application of Carbonization Technology in Medical Waste Treatment as a Sustainable Waste to Energy Conversion in Indonesia
Author : Awanis Mazayasina Ardhistira, Muhammad Sulaiman Ardhianto, Raissa Anindya Azzahra, and Tifari Athia Zahra

Abstract : As the second-highest country with COVID-19 cases in Southeast Asia, medical waste (MW) generated by healthcare facilities in Indonesia has increased to 425 tons/day from 290 tons/day in 2019. Inefficient current methods for MW treatment (incineration and land disposal) emit dioxins, contributing to environmental issues and health deterioration. On the contrary, carbonization can effectively convert MW into valuable products specifically char with an estimated HHV up to 25 MJ/kg, similar with that of sub-bituminous coal, while operating under mild conditions. In the absence of oxygen, over 50% of the carbon is recovered as solid product, therefore decreasing the emitted gaseous carbons. This study will analyze technical and environmental aspects of various carbonization techniques and provide recommendation for the most suitable technique to be implemented. The solution aims to give impact for energy production and environmental preservation as a strategy in achieving sustainable waste to energy conversion in Indonesia.

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