the Effects of Red Fruit Treatment on Infertility Mice Models to Overview Folliculogenesis, Estrous Cycle and Pregnancy Rate

Saiful Rizal, Gagang Ichwanul Akbar, Diana Nurjanah

Abstract


The aims of this research is to determine of therapeutics effect of red fruit addition in infertility mice models that can increase foliculogenesis and increasing pregnant rate. The experimental animal used are 24 female mice with 25 gram average body weight. The treatment divided into 4 groups and each group gets 6 repetitions. The control group (P0) is given only aquadest without getting treatment. P1 group were given injections of testosterone propionate 1 mg / kg subcutan (sc) for 14 days for the effects of infertility. The treatment group P2 and P3 have an injection of testosterone propionate 1 mg / kg subcutan (sc) for 14 days to effect, infertility and given a red fruit extract therapeutic dose of 0.05 ml and 0.1 ml for 14 days in orally. Testosterone propionate were injected as much as 0.02 ml subcutan conducted for 14 days. The parameters used are estrus cycle between infertility mice that given treated with red fruit and mice infertility without given treated with red fruit and diameters of pre antral and antral follicle. The data were analysed using ANOVA(analysis of variance). The result showed there are significant estrus cycle between infertility mice that given treated with red fruit and mice infertility without given treated with red fruit. However, analysis of data from the ovary preparations showed no significant difference between the number of follicles either primary follicle, and follicle de graaf, but for secondary

follicles was significantly different between the K (-) with K(+). 


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