Nanoencapsulation Of Graviola (Annona Muricata L.) Seed By- Products Ethanolic Extract For Breast Cancer Activity

Noviani Nurma Arif, Arinda Dwi Rizki, Dhina Fitriastuti


Breast cancer is the most second prevalent cancer worldwide and causes high numbers of deaths among woman every year. According to the World Health Organization (WHO), approximately 8-9% woman worldwide have an affected breast cancer. Annona muricata L. commonly known as Graviola has demonstrated that the seed use of natural products as anticancer agents in breast cancer. The bioactive compound such as flavonoids in Graviola reported exhibiting potent and uncommon selective growth inhibition against of breast cancer. This research to a known formula of nanoencapsulation of ethanolic seed extract of Annona muricata L. Using phytochemical screening, nanoencapsulation method, and Particle Size Analyzer (PSA). Phytochemical screening was conducted using qualitative methods to assign the relative abundance of the different phytochemicals. The nanoencapsulation process was using thin layer method to improve functionality as anticancer. The nanoencapsulation size and stabilities of Graviola seed extract are measured by Particle Size Analyzer. Phytochemical screening of the extract revealed that the seed has secondary class metabolite compounds such as alkaloids, flavonoids, phenolics, and saponins. The nanoencapsulation process was made using ethanolic extract and maltodextrin with formula 1:1, 1:2 , 1:3 , and 1:4. The result showed nanoencapsulation with formula 1:1 had Z-average 11,1 nm; Pi value 0,187 ; and the stability of nanoencapsulation product have shown by zeta potential -44,4 mV. The data showed that seed extract of Graviola has beneficial properties in alternative medicine for breast cancer.

Full Text:



Alassane W, Yanjun Z, Caux C, Brouard JP, Pousset JL, Bodo B (2004). “Annomuricatin C, a novel cyclohexapeptide from the seeds of Annona muricata”. C R Chimie, 7:981-988

Duraipandiyan V, Ayyanar M, Ignacimuthu S (2006). “Antimicrobial activity of some ethnomedical plants used by paliyar tribe from Tamil Nadu, India”. BMC Compl Alternat Med. doi:10.1186/1472-6882-6-35.635

Eisenberg DM, Davis RB, Ettner SL, et al (1998). “Trends in alternative medicine use in the United States, 1990-1997: result of a follow-up national survey”. J Am Med Assoc, 280, 1569-75

Weiss J, Takhistov P, McClements DJ (2006). “Functional materials in food nanotechnology”, J Food SCI. 71: 107-116


  • There are currently no refbacks.